ironjustice
2013-04-29 00:41:15 UTC
"Survival rates of patients who had serum transferrin ≥190 mg/dL (MST,
12.0 months) were significantly better than those of patients who had
serum transferrin<190 mg/dL"
Serum transferrin as a predictor of prognosis for hepatic arterial
infusion chemotherapy in advanced hepatocellular carcinoma
Zaitsu J, Yamasaki T, Saeki I, Harima Y, Iwamoto T, Harima Y,
Matsumoto T, Urata Y, Hidaka I, Marumoto Y, Ishikawa T, Takami T,
Yamamoto N, Kaino S, Uchida K, Terai S, Sakaida I
Hepatology Research (Apr 2013)
AIM: We recently reported that the iron chelator deferoxamine (DFO) is
efficacious in advanced hepatocellular carcinoma (HCC) patients. Iron
regulation may thus have an important impact in HCC therapy. Because
transferrin is a native chelator that regulates iron homeostasis, it
may act as an anti-cancer agent in a similar manner as DFO. The
objective of this study was to evaluate serum transferrin as a
prognostic predictor in advanced HCC patients undergoing hepatic
arterial infusion chemotherapy (HAIC).
METHODS: We retrospectively studied 44 patients receiving HAIC and
analyzed various parameters for their possible use as prognostic
predictors.
RESULTS: The 1-, 2-, and 3-year cumulative survival rates were 36.4%,
18.2%, and 8.5%, respectively, and the median survival time (MST) was
7.0 months. The survival rates of patients who had serum transferrin
≥190 mg/dL (MST, 12.0 months) were significantly better than those of
patients who had serum transferrin<190 mg/dL (MST, 4.9 months).
Multivariate analysis identified serum transferrin ≥190 mg/dL [hazard
ratio (HR), 0.282; 95% confidence interval (CI), 0.132-0.603; P =
0.001] and Child-Pugh score B (HR, 1.956; 95% CI, 1.034-3.700; P =
0.039) as independent prognostic predictors. There was a significant
correlation between serum transferrin level and therapeutic effect
(P<0.001).
CONCLUSIONS: Serum transferrin could be useful as a prognostic
predictor in advanced HCC patients before HAIC treatment.
-----------------
"A patient with an increased serum transferrin level often suffers
from iron deficiency anemia."
http://en.wikipedia.org/wiki/Transferrin
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
12.0 months) were significantly better than those of patients who had
serum transferrin<190 mg/dL"
Serum transferrin as a predictor of prognosis for hepatic arterial
infusion chemotherapy in advanced hepatocellular carcinoma
Zaitsu J, Yamasaki T, Saeki I, Harima Y, Iwamoto T, Harima Y,
Matsumoto T, Urata Y, Hidaka I, Marumoto Y, Ishikawa T, Takami T,
Yamamoto N, Kaino S, Uchida K, Terai S, Sakaida I
Hepatology Research (Apr 2013)
AIM: We recently reported that the iron chelator deferoxamine (DFO) is
efficacious in advanced hepatocellular carcinoma (HCC) patients. Iron
regulation may thus have an important impact in HCC therapy. Because
transferrin is a native chelator that regulates iron homeostasis, it
may act as an anti-cancer agent in a similar manner as DFO. The
objective of this study was to evaluate serum transferrin as a
prognostic predictor in advanced HCC patients undergoing hepatic
arterial infusion chemotherapy (HAIC).
METHODS: We retrospectively studied 44 patients receiving HAIC and
analyzed various parameters for their possible use as prognostic
predictors.
RESULTS: The 1-, 2-, and 3-year cumulative survival rates were 36.4%,
18.2%, and 8.5%, respectively, and the median survival time (MST) was
7.0 months. The survival rates of patients who had serum transferrin
≥190 mg/dL (MST, 12.0 months) were significantly better than those of
patients who had serum transferrin<190 mg/dL (MST, 4.9 months).
Multivariate analysis identified serum transferrin ≥190 mg/dL [hazard
ratio (HR), 0.282; 95% confidence interval (CI), 0.132-0.603; P =
0.001] and Child-Pugh score B (HR, 1.956; 95% CI, 1.034-3.700; P =
0.039) as independent prognostic predictors. There was a significant
correlation between serum transferrin level and therapeutic effect
(P<0.001).
CONCLUSIONS: Serum transferrin could be useful as a prognostic
predictor in advanced HCC patients before HAIC treatment.
-----------------
"A patient with an increased serum transferrin level often suffers
from iron deficiency anemia."
http://en.wikipedia.org/wiki/Transferrin
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk