Post by Old Bill|
| | >
| > Later I had to give blood for haematology.My paraprotein
| > M-spike marker had risen by an alarming 72%.
| >
| > All I wanted was some cough drops/
|
| Garlic affects the blood http://en.wikipedia.org/wiki/Garlic
| Thanks for confirming it is still MGUS (gammopathy), not myeloma.
| Asking the right questions takes up too much of their time.
| J
|
I did not say I still have gammopathy,
Oh, good (I think).
"The level of the spike is important, because older people may show low
levels of a spike without having myeloma"
http://www.fmh.org/oncology.cfm?id=59
Immunoglobulins: Immunoglobulins are antibodies, which are blood proteins
normally made by immune system cells to help fight germs. There are several
types of immunoglobulins, including IgA, IgG, IgD, and IgM. Bone marrow
cancers such as multiple myeloma and Waldenstrom macroglobulinemia often
result in too many immunoglobulins in the blood (as well as in the urine).
A high level of immunoglobulins may indicate the presence of one of these
diseases.
There are normally many different immunoglobulins in the blood, with each
one differing very slightly from the others. A classic sign in patients
with myeloma or macroglobulinemia is that all the globulins are alike (that
is, they are monoclonal). This can be seen on a test called protein
electrophoresis, which separates the globulins by electrical current. With
myeloma or macroglobulinemia, the globulins (also called monoclonal proteins
or M proteins) stick together and form a monoclonal "spike" (M spike) on the
readout of the test. The level of the spike is important, because older
people may show low levels of a spike without having myeloma or
macroglobulinemia. The diagnosis, however, must be confirmed by a biopsy of
the bone marrow.
Immunoglobulin levels can also be followed over time to help determine how
well treatment is working.
It's also useful in heart diagnostics ?
http://ukpmc.ac.uk/classic/articlerender.cgi?artid=1091452
Cardiomyopathic disorders are associated with predominantly systolic or
diastolic dysfunction, or with both. In hypertrophic cardiomyopathy, which
is initially associated with predominant diastolic dysfunction,26 we
recently reported increased concentrations of cTnT in 50% of patients during
the non-dilated phase of the disease, when systolic function was preserved,
and in the absence of ischaemia.27 Some patients had increased cTnT
concentrations persisting over several years of follow up, during which
fractional shortening and intraventricular septum thickness decreased
significantly. These observations indicate that cTnT is a marker of myocyte
injury in patients with hypertrophic cardiomyopathy. In a univariate
analysis, Dispenzieri and colleagues found cTnT, cTnI, septal thickness,
left ventricular ejection fraction, urine M spike, age, and symptoms of
congestive heart failure to be significant predictors of overall survival in
patients with cardiac amyloidosis, while in multivariate analysis, the
detection of cTnT was the most reliable predictor.28"
So when was the cough happening? Lying down?
Still a problem?
J