Iron And Cancer

[ironjustice]

Iron and cancer: more ore to be mined.
Torti SV, Torti FM.
Nat Rev Cancer. 2013 Apr 18. doi: 10.1038/nrc3495.
Departments of Molecular, Microbial and Structural Biology,
Farmington, Connecticut 06030, USA.

Abstract
Iron is an essential nutrient that facilitates cell proliferation and
growth. However, iron also has the capacity to engage in redox cycling
and free radical formation.
Therefore, iron can contribute to both tumour initiation and tumour
growth; recent work has also shown that iron has a role in the tumour
microenvironment and in metastasis.
Pathways of iron acquisition, efflux, storage and regulation are all
perturbed in cancer, suggesting that reprogramming of iron metabolism
is a central aspect of tumour cell survival.
Signalling through hypoxia-inducible factor (HIF) and WNT pathways may
contribute to altered iron metabolism in cancer.
Targeting iron metabolic pathways may provide new tools for cancer
prognosis and therapy.

PMID:23594855


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DEAD PEOPLE WALKING
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[John H. Gohde]

Post by ironjustice
Iron and cancer: more ore to be mined.
Torti SV, Torti FM.
Nat Rev Cancer. 2013 Apr 18. doi: 10.1038/nrc3495.
Departments of Molecular, Microbial and Structural Biology,
Farmington, Connecticut 06030, USA.
Abstract
Iron is an essential nutrient that facilitates cell proliferation and
growth. However, iron also has the capacity to engage in redox cycling
and free radical formation.
Therefore, iron can contribute to both tumour initiation and tumour
growth; recent work has also shown that iron has a role in the tumour
microenvironment and in metastasis.
Pathways of iron acquisition, efflux, storage and regulation are all
perturbed in cancer, suggesting that reprogramming of iron metabolism
is a central aspect of tumour cell survival.
Signalling through hypoxia-inducible factor (HIF) and WNT pathways may
contribute to altered iron metabolism in cancer.
Targeting iron metabolic pathways may provide new tools for cancer
prognosis and therapy.
PMID:23594855
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

Can YOU spell vitamin D, Science Psycho?